Cerebellar atrophy and its implications on gait in cerebral amyloid angiopathy.
Mitchell J HornElif GokcalAlex J BeckerAlvin S DasAndrew D Warrennull nullKristin SchwabJoshua N GoldsteinAlessandro BiffiJonathan RosandJonathan R PolimeniAnand ViswanathanSteven M GreenbergM Edip GurolPublished in: Journal of neurology, neurosurgery, and psychiatry (2022)
Patients with CAA show more subcortical cerebellar atrophy than HC or patients with AD and more cortical cerebellar atrophy than HCs. Reduced pCbll-ScV correlated with lower gait velocity in regression models including other relevant variables. Overall, this study suggests that CAA causes cerebellar injury, which might contribute to gait disturbance.