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A meta-analysis of two high-risk prospective cohort studies reveals autism-specific transcriptional changes to chromatin, autoimmune, and environmental response genes in umbilical cord blood.

Charles E MordauntBo Y ParkKelly M BakulskiJason I FeinbergLisa A CroenChristine Ladd-AcostaCraig J NewschafferHeather E VolkSally OzonoffIrva Hertz-PicciottoJanine M LaSalleRebecca J SchmidtM Daniele Fallin
Published in: Molecular autism (2019)
This is the first study to identify gene expression differences in cord blood specific to ASD through a meta-analysis across two prospective pregnancy cohorts. The enriched gene pathways support involvement of environmental, immune, and epigenetic mechanisms in ASD etiology.
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