A meta-analysis of two high-risk prospective cohort studies reveals autism-specific transcriptional changes to chromatin, autoimmune, and environmental response genes in umbilical cord blood.
Charles E MordauntBo Y ParkKelly M BakulskiJason I FeinbergLisa A CroenChristine Ladd-AcostaCraig J NewschafferHeather E VolkSally OzonoffIrva Hertz-PicciottoJanine M LaSalleRebecca J SchmidtM Daniele FallinPublished in: Molecular autism (2019)
This is the first study to identify gene expression differences in cord blood specific to ASD through a meta-analysis across two prospective pregnancy cohorts. The enriched gene pathways support involvement of environmental, immune, and epigenetic mechanisms in ASD etiology.
Keyphrases
- gene expression
- autism spectrum disorder
- cord blood
- umbilical cord
- genome wide
- dna methylation
- mesenchymal stem cells
- intellectual disability
- attention deficit hyperactivity disorder
- genome wide identification
- transcription factor
- copy number
- multiple sclerosis
- dna damage
- life cycle
- preterm birth
- pregnant women
- case control
- genome wide analysis
- heat shock
- bioinformatics analysis
- heat stress