Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy.
Abraham NissaniShaked Lev-AriTomer MeirsonElad JacobyNethanel AsherGuy Ben-BetzalelOrit ItzhakiRonnie Shapira-FrommerJacob SchachterGal MarkelMichal J BesserPublished in: Journal for immunotherapy of cancer (2022)
Bone marrow depletion and recovery were equally affected by 120Cy/125Flu and 60Cy/125Flu preconditioning; however, toxicity and consequently duration of hospitalization were significantly lower in the 60Cy/125Flu cohort. Patients in the 30Cy/75Flu and TBI/75Flu groups rarely developed NMA-induced adverse events; however, both regimens were not efficient in achieving deep bone marrow suppression. Among the regimens, 60Cy/125Flu preconditioning seems to achieve maximum effect with minimum toxicity.
Keyphrases
- cell therapy
- bone marrow
- mesenchymal stem cells
- patients undergoing
- ischemia reperfusion injury
- end stage renal disease
- stem cells
- traumatic brain injury
- cerebral ischemia
- chronic kidney disease
- ejection fraction
- newly diagnosed
- high glucose
- prognostic factors
- low dose
- acute lymphoblastic leukemia
- blood brain barrier
- diabetic rats