Reliable and rapid identification of terbinafine resistance in dermatophytic nail and skin infections.

Gabriela BlanchardBoyko AmarovMarina FrattiKarine SalaminOlympia BontemsYun-Tsan ChangAlina Marcela SabouNathalie KünzleMichel MonodEmmanuella Guenova

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2023)

Based on our data, we propose MIC of 0·015 μg/ml as a minimum breakpoint for predicting clinically relevant terbinafine treatment failure to standard oral dosing for dermatophyte infections. We further propose growth on Sabouraud dextrose agar medium containing 0·2 μg/ml terbinafine and SQLE sequencing as fungal sporulation-independent methods for rapid and reliable detection of terbinafine resistance.

Keyphrases

loop mediated isothermal amplification
electronic health record
sensitive detection
single cell
combination therapy
big data
quantum dots
real time pcr
wound healing
data analysis