Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance.
Jelena RemeticAhmed GhallabZaynab HoblossLisa BrackhagenReham HassanMaiju MyllysRichard RadunVeronika MlitzCi ZhuMaximilian BaumgartnerWaltraud C SchrottmaierMarion MussbacherGerald TimelthalerHubert ScharnaglTatjana StojakovicAlice AssingerClaudia D FuchsJan G HengstlerMichael TraunerPublished in: Hepatology (Baltimore, Md.) (2022)
Absence of Bsep and cholestasis in general impair LPS clearance by a basolateral uptake block into hepatocytes and consequently less secretion into canaliculi. Impaired LPS removal aggravates hepatic inflammation in cholestasis.