Survivin-specific CD4+ T cells are decreased in patients with survivin-positive myeloma.

Frederick L LockeMeghan MengesAnandharaman VeerapathranDomenico CoppolaDmitry GabrilovichClaudio Anasetti

Published in: Journal for immunotherapy of cancer (2015)

We have, for the first time, quantified the circulating CD4+CD25- precursor frequency against survivin and demonstrated this is lower in myeloma patients than healthy donors. The number of survivin reactive CD4+CD25- T cells is inversely associated with tumor survivin expression suggesting suppression of survivin responsive CD4+CD25- T cells. Further exploration of a full length mutant survivin protein vaccine which expands survivin reactive CD4+ cells independent of the survivin reactive precursor frequency is warranted.

Keyphrases

newly diagnosed
induced apoptosis
end stage renal disease
oxidative stress
small molecule
binding protein
nk cells
patient reported outcomes