A combination of herbal compound (SPTC) along with exercise or metformin more efficiently alleviated diabetic complications through down-regulation of stress oxidative pathway upon activating Nrf2-Keap1 axis in AGE rich diet-induced type 2 diabetic mice.
Golbarg RahimiSalime HeydariBahareh RahimiNavid AbedpoorIman NiktabZahra SafaeinejadMaryam PeymaniFarzad Seyed ForootanZahra DerakhshanMohammad Hossein Nasr EsfahaniKamran GhaediPublished in: Nutrition & metabolism (2021)
Eventually, combined treatment of SPTC with exercise or metformin as a novel approach had more beneficial effects to prevent the development of diabetes and oxidative stress associated with hyperglycemia.
Keyphrases
- oxidative stress
- high intensity
- type diabetes
- physical activity
- diabetic rats
- resistance training
- cardiovascular disease
- signaling pathway
- dna damage
- ischemia reperfusion injury
- risk factors
- wound healing
- induced apoptosis
- body composition
- stress induced
- skeletal muscle
- small molecule
- weight loss
- smoking cessation
- endoplasmic reticulum stress