Single-nucleus transcriptome analysis reveals disease- and regeneration-associated endothelial cells in white matter vascular dementia.

Daniel Nicolae Mitroi Min TianRiki KawaguchiWilliam E Lowry S Thomas Carmichael

Published in: Journal of cellular and molecular medicine (2022)

This comprehensive molecular profiling of brain samples from patients with VaD reveals previously unknown molecular changes in cells of the neurovascular niche, and an attempt at regeneration in injured white matter.

Keyphrases

white matter
multiple sclerosis
stem cells
endothelial cells
induced apoptosis
cell cycle arrest
mild cognitive impairment
cognitive impairment
single molecule
single cell
wound healing
endoplasmic reticulum stress
high glucose
resting state
functional connectivity
cell proliferation