Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 Activity.
Haisheng YuMengqi LiRui HePeining FangQiming WangYu YiFubing WangLi ZhouYi ZhangAidong ChenNanfang PengDan LiuMirko TrillingRuth BroeringErik A C WiemerMengji LuYing ZhuShi LiuPublished in: Hepatology (Baltimore, Md.) (2020)
Taken together, through the sequestration of IRF2, MVP promotes an HDM2-dependent loss of p53 that promotes HCC development.