Symmetric dimeric bisbenzimidazoles DBP(n) reduce methylation of RARB and PTEN while significantly increase methylation of rRNA genes in MCF-7 cancer cells.

Svetlana V KostyukMargarita A KvashaDaria A KhrabrovaOlga V KirsanovaElizaveta S ErshovaElena M MalinovskayaNatalia N VeikoAlexander A IvanovVasiliy S KovalAlexei L ZhuzeVadim H TashlitskyPavel E UmriukhinSergey I KutsevElizaveta S Gromova

Published in: PloS one (2018)

It is concluded that DBP (n) are able to accumulate in the nucleus (excluding the nucleolus area) and in the mitochondria of cancer cells, reducing mitochondrial potential. The DBP (n) induce the demethylation of a cancer cell's genome, including the demethylation of the promoters of tumor suppressor genes. DBP (n) significantly increase the methylation of ribosomal RNA genes in the nucleoli. Therefore the further study of these compounds is needed; it could lead to the creation of new anticancer agents.

Keyphrases

genome wide
dna methylation
bioinformatics analysis
genome wide identification
oxidative stress
cell death
gene expression
breast cancer cells
transcription factor
human health
pi k akt
nucleic acid