Ultrahigh-Resolution Homo- and Heterodecoupled 1 H and TOCSY NMR Experiments.

The original homonuclear decoupled (pure shift) experiments provide ultrahigh-resolution 1 H spectra of compounds containing NMR-active heteronuclei of low natural isotopic abundance (e.g., 13 C or 15 N). In contrast, molecules containing highly abundant heteronuclei (like 31 P or 19 F) give doublets or a multiple of doublets in their homonuclear decoupled spectra, depending on the number of heteronuclear coupling partners and the magnitude of the respective coupling constants. In these cases, the complex and frequently overlapping signals may hamper the unambiguous assignment of resonances. Here, we present new heteronuclear decoupled (HD) PSYCHE 1 H and TOCSY experiments, which result in simplified spectra with significantly increased resolution, allowing the reliable assessment of individual resonances. The utility of the experiments has been demonstrated on a challenging stereoisomeric mixture of a platinum-phosphine complex, where ultrahigh resolution of the obtained HD PSYCHE spectra made the structure elucidation of the chiral products feasible. HD PSYCHE methods can be potentially applied to other important 31 P- or 19 F-containing compounds in medicinal chemistry and metabolomics.