Chronic Naltrexone Therapy Is Associated with Improved Cardiac Function in Volume Overloaded Rats.

Lukas DeheMohammed ShaquraMichael NordineHelmut HabazettlPetra von KwiatkowskiHelena SchluchterMehdi ShakibaeiShaaban A MousaMichael SchäferSascha Treskatsch

Published in: Cardiovascular drugs and therapy (2021)

Opioid receptor blockade by naltrexone leads to improved LV function and decreases in rBNP-45 and angiotensin-2 plasma levels. In parallel, naltrexone resulted in opioid receptor mRNA downregulation and an elevated intrinsic tone of endogenous opioid peptides possibly reflecting a potentially cardiodepressant effect of the cardiac opioid system during volume overload.

Keyphrases

chronic pain
pain management
cell proliferation
left ventricular
binding protein
signaling pathway
stem cells
atrial fibrillation
bone marrow
amino acid
smoking cessation
replacement therapy