Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats.

Yanshuang LiuYingran LiangBin ZhengLi ChuDonglai MaHongfang WangXi ChuJianping Zhang

Published in: Drug design, development and therapy (2020)

These findings suggest that crocetin ameliorates ATO-induced hepatic injury in rats. In addition, the effect of crocetin might be related to its role in antioxidant stress, as an anti-inflammatory agent, and in regulating the Nrf2 signaling pathway.

Keyphrases

oxidative stress
diabetic rats
signaling pathway
induced apoptosis
anti inflammatory
high glucose
ischemia reperfusion injury
dna damage
pi k akt
epithelial mesenchymal transition
drug induced
drinking water
heavy metals
heat shock
cell proliferation
endoplasmic reticulum stress
heat stress