Clinically Significant CUX1 Mutations Are Frequently Subclonal and Common in Myeloid Disorders With a High Number of Co-mutated Genes and Dysplastic Features.

Josephine Kam Tai K DermawanChristine WenselValeria VisconteJaroslaw P MaciejewskiJames R CookDavid S Bosler

Published in: American journal of clinical pathology (2021)

CUX1 mutations are seen with adverse prognostic features and could be a late clonal evolutional event of myeloid disorders. The differences between CUX1 tier I/tier II and VUS underscore the importance of accurate variant classification in reporting of multigene panels.

Keyphrases

dendritic cells
bone marrow
acute myeloid leukemia
machine learning
adverse drug
deep learning
genome wide
immune response
bioinformatics analysis
mass spectrometry
genome wide analysis