Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease.

Ming LiChen LyuManyan HuangCatherine DoBenjamin TyckoPhilip J LupoStewart L MacLeodChristopher E RandolphNianjun LiuJohn S WitteCharlotte A Hobbs

Published in: BMC genomic data (2021)

Our results support the hypothesis that genetic variants may influence the risk of CHDs through regulating the changes of DNA methylation and gene expression. Our results can serve as an important source of information that can be integrated with other genetic studies of heart diseases, especially CHDs.

Keyphrases

genome wide
dna methylation
congenital heart disease
gene expression
high resolution
copy number
heart failure
left ventricular
atrial fibrillation
high density
case control