Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induced pulmonary endothelial glycocalyx loss via ALX/SIRT1/NF-kappa B axis.
Xin-Yang WangXin-Yu LiCheng-Hua WuYu HaoPan-Han FuHong-Xia MeiFang ChenYu-Qiang GongSheng-Wei JinHui LiPublished in: Respiratory research (2021)
PCTR1 protects endothelial glycocalyx via ALX receptor by regulating SIRT1/NF-κB pathway, suggesting PCTR1 may be a significant therapeutic target for sepsis-related acute lung injury.
Keyphrases
- lipopolysaccharide induced
- inflammatory response
- lps induced
- nuclear factor
- oxidative stress
- signaling pathway
- toll like receptor
- endothelial cells
- stem cells
- ischemia reperfusion injury
- pi k akt
- pulmonary hypertension
- acute kidney injury
- intensive care unit
- septic shock
- cell proliferation
- cancer therapy
- binding protein
- wound healing
- drug delivery