ILK inhibition reduces osteophyte formation through suppression of osteogenesis in BMSCs via Akt/GSK-3β/β-catenin pathway.

Zhi-Xiang Huang Lixin Huang Jiali Ding Yukai Huang Xuechan Huang Tian-Wang Li

Published in: Molecular biology reports (2024)

ILK inhibition lowered osteogenesis in TNF-α-related inflammatory conditions by deactivating the Akt/ GSK-3β/ β-catenin pathway. This may be a potential strategy to alleviate osteophyte development in addition to anti-inflammatory treatment.

Keyphrases

signaling pathway
pi k akt
anti inflammatory
cell proliferation
rheumatoid arthritis
oxidative stress
combination therapy
replacement therapy
drug induced