Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes.
Andrew R DiNardoTanmay GandhiJan HeyckendorfSandra L GrimmKimal RajapaksheTomoki NishiguchiMaja ReimannH Lester KirchnerJaqueline KahariQiniso DlaminiChristoph LangeTorsten GoldmannSebastian Marwitznull null. AbhimanyuJeffrey D CirilloStefan H E KaufmannMihai G NeteaReinout van CrevelAnna Maria MandalakasCristian CoarfaPublished in: The European respiratory journal (2022)
These findings provide evidence that metabolic and immune profiling could inform optimisation of endotype-specific host-directed therapies for tuberculosis.