From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards.

Júlia Perera-BelBarbara HutterChristoph HeiningAnnalen BleckmannMartina FröhlichStefan FröhlingHanno GlimmBenedikt BrorsTim Beißbarth

Published in: Genome medicine (2018)

We believe that a standardized method to report actionable somatic variants will smooth the incorporation of NGS in the clinical context. We anticipate that tools like the one we present here will become essential in summarizing for clinicians the growing evidence in the field of precision medicine. The R code of the presented method is provided in Additional file 6 and available at https://github.com/jperera-bel/MTB-Report .

Keyphrases

copy number
palliative care
mycobacterium tuberculosis
genome wide
dna methylation
emergency department
adverse drug
gene expression
single molecule
drug induced