CD40 agonist-induced IL-12p40 potentiates hepatotoxicity.

Caroline BonnansGraham ThomasWenqian HeBreanna JungWei ChenMin LiaoJonathan HeyenBernard BuetowSmitha PillaiDiane MatsumotoJavier Chaparro-RiggersShahram Salek-ArdakaniYan Qu

Published in: Journal for immunotherapy of cancer (2021)

As clinical research programs aim to circumnavigate toxicity concerns while maintaining antitumor efficacy it will be essential to understand which features of CD40 biology mediate antitumor function to develop both safe and efficacious agonists.

Keyphrases

drug induced
oxidative stress
nk cells
diabetic rats
public health
stress induced