How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?
Sajad YaghoubiHamid NajminejadMehran DabaghianMohammad Hossein KarimiMeghdad Abdollahpour-AlitappehFariba RadMotahareh Mahi-BirjandShiva MohammadiFatemeh MohseniMohammad Sobhani LariGholam Hossein TeymouriEsmat Rigi YousofabadiAbbas SalmaniNader BagheriPublished in: IUBMB life (2020)
Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell-derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.
Keyphrases
- mesenchymal stem cells
- stem cells
- induced apoptosis
- endothelial cells
- ischemia reperfusion injury
- signaling pathway
- cerebral ischemia
- cell therapy
- bone marrow
- squamous cell carcinoma
- papillary thyroid
- young adults
- cell death
- brain injury
- epithelial mesenchymal transition
- vascular endothelial growth factor
- quality improvement