Sheet-like 2D Manganese(IV) Complex with High Photothermal Conversion Efficiency.
Ye XuChao LiXiaoyu WuMing-Xing LiYunsheng MaHong YangQing-Dao ZengJonathan L SesslerZhao-Xi WangPublished in: Journal of the American Chemical Society (2022)
We report a stable, water-soluble, mononuclear manganese(IV) complex [Mn IV (H 2 L )]·5H 2 O (Mn-HDCL) that acts as an efficient photothermal material. This system is based on a hexahydrazide clathrochelate ligand ( L /HDCL) and is obtained via an efficient one-pot templated synthesis that avoids the need for harsh reaction conditions. Scanning tunneling microscopy images reveal that Mn-HDCL exists as a 2D sheet-like structure. In Mn-HDCL, the manganese(IV) ion is trapped within the cavity of the cage-like ligand. This effectively shields the Mn(IV) ion from the external environment while providing adequate water solubility. As a result of orbital transitions involving the coordinated manganese(IV) ion, as well as metal-to-ligand charge transfer effects, Mn-HDCL possesses a large extinction coefficient and displays a photothermal performance comparable to single-wall carbon nanotubes in the solid state. A high photothermal conversion efficiency (ca. 71%) was achieved in aqueous solution when subjected to near-infrared 730 nm laser photo-irradiation. Mn-HDCL is paramagnetic and provides a modest increase in the T 1 -weighted contrast of magnetic resonance images both in vitro and in vivo . Mn-HDCL was found to target tumors passively and allow tumor margins to be distinguished in vivo in a mouse model. In addition, it also exhibited an efficient laser-triggered photothermal therapy effect in vitro and in vivo . We thus propose that Mn-HDCL could have a role to play as a tumor-targeting photothermal sensitizer.
Keyphrases
- photodynamic therapy
- magnetic resonance
- room temperature
- cancer therapy
- transition metal
- metal organic framework
- drug delivery
- drug release
- mouse model
- water soluble
- solid state
- optical coherence tomography
- gene expression
- radiation therapy
- single cell
- oxide nanoparticles
- genome wide
- peripheral blood
- diffusion weighted imaging