Beyond antiviral: Interferon induced by bacteria maintains tolerance in the gut.
Yi YangKen H CadwellPublished in: The Journal of experimental medicine (2023)
Type I interferons are best known for their antiviral role. Here, Ayala et al. (https://doi.org/10.1084/jem.20230063) reveal that commensal bacteria elicit tonic type I interferons to prime dendritic cells and induce regulatory T cells that maintain a tolerogenic intestinal milieu.