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Beyond antiviral: Interferon induced by bacteria maintains tolerance in the gut.

Yi YangKen H Cadwell
Published in: The Journal of experimental medicine (2023)
Type I interferons are best known for their antiviral role. Here, Ayala et al. (https://doi.org/10.1084/jem.20230063) reveal that commensal bacteria elicit tonic type I interferons to prime dendritic cells and induce regulatory T cells that maintain a tolerogenic intestinal milieu.
Keyphrases
  • dendritic cells
  • regulatory t cells
  • immune response
  • genome wide
  • gene expression