Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A.
Frederick A BagdasarianHanne Demant HansenJingyuan ChenChi-Hyeon YooMichael S PlaczekJacob M HookerHsiao-Ying WeyPublished in: ACS chemical neuroscience (2024)
The extent of changes in functional connectivity (FC) within functional networks as a common feature across hallucinogenic drug classes is under-explored. This work utilized fMRI to assess the dissociative hallucinogens Psilocybin, a classical serotonergic psychedelic, and Salvinorin-A, a kappa-opioid receptor (KOR) agonist, on resting-state FC in nonhuman primates. We highlight overlapping and differing influence of these substances on FC relative to the thalamus, claustrum, prefrontal cortex (PFC), default mode network (DMN), and DMN subcomponents. Analysis was conducted on a within-subject basis. Findings support the cortico-claustro-cortical network model for probing functional effects of hallucinogens regardless of serotonergic potential, with a potential key paradigm centered around the claustrum, PFC, anterior cingulate cortices (ACC), and angular gyrus relationship. Thalamo-cortical networks are implicated but appear dependent on 5-HT 2A R activation. Acute desynchronization relative to the DMN for both drugs was also shown. Our findings provide a framework to understand broader mechanisms at which hallucinogens in differing classes may impact subjects regardless of the target receptor.
Keyphrases
- functional connectivity
- resting state
- prefrontal cortex
- liver failure
- drug induced
- respiratory failure
- aortic dissection
- machine learning
- chronic pain
- human health
- pain management
- nuclear factor
- hepatitis b virus
- drinking water
- risk assessment
- deep brain stimulation
- molecular dynamics simulations
- deep learning
- intensive care unit
- emergency department
- extracorporeal membrane oxygenation
- climate change
- mechanical ventilation