Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S-sulfhydration in ApoE-knockout atherosclerotic mice.

Jinhui FanFengjiao ZhengShuangyue LiCangting CuiShan JiangJun ZhangYue DengQinghua CuiJichun YangXinjing TangGuoheng XuBin Geng

Published in: British journal of pharmacology (2019)

Sulfhydration or nitrosylation of CSE represents a yin/yang regulation of catalysis or binding to L-homocysteine. H2 S donor treatment enhanced CSE sulfhydration, thus lowering serum L-homocysteine, which contributed in part to the anti-atherosclerosis effects in ApoE-knockout mice with hyperhomocysteinemia.

Keyphrases

cognitive decline
high fat diet
cardiovascular disease
high fat diet induced
adipose tissue
wild type
mild cognitive impairment
metabolic syndrome
combination therapy
smoking cessation