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Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S-sulfhydration in ApoE-knockout atherosclerotic mice.

Jinhui FanFengjiao ZhengShuangyue LiCangting CuiShan JiangJun ZhangYue DengQinghua CuiJichun YangXinjing TangGuoheng XuBin Geng
Published in: British journal of pharmacology (2019)
Sulfhydration or nitrosylation of CSE represents a yin/yang regulation of catalysis or binding to L-homocysteine. H2 S donor treatment enhanced CSE sulfhydration, thus lowering serum L-homocysteine, which contributed in part to the anti-atherosclerosis effects in ApoE-knockout mice with hyperhomocysteinemia.
Keyphrases
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