Obesity is associated with severe clinical course in children with Henoch-Schonlein purpura.

Hatice Adiguzel DundarMehmet PektancMeral Torun BayramAlper SoyluSalih Kavukcu

Published in: Pediatric nephrology (Berlin, Germany) (2020)

Obese children with HSP had higher erythrocyte sedimentation rate, hypertension, and severe renal involvement; showed delayed improvement of skin, joint, and kidney findings; and need more immunosuppressive medications and a longer period of steroid treatment. These findings may be associated with the effect of adipose tissue on inflammation.

Keyphrases

adipose tissue
insulin resistance
metabolic syndrome
weight loss
young adults
type diabetes
blood pressure
early onset
oxidative stress
high fat diet
heat shock protein
drug induced
soft tissue
high fat diet induced
combination therapy