Role of ceramide-to-dihydroceramide ratios for insulin resistance and non-alcoholic fatty liver disease in humans.
Maria ApostolopoulouRuth GordilloSofiya GanchevaKlaus StrassburgerChristian HerderIrene EspositoMatthias SchlensakJan-Bernd FunckeMichael RodenPublished in: BMJ open diabetes research & care (2021)
These results failed to confirm the relationships of ceramide/dihydroceramide in humans with different degree of insulin resistance. However, the low hepatic ceramide/dihydroceramide favor a role for dihydroceramide accumulation in NASH, while a specific ceramide/dihydroceramide ratio in visceral adipose tissue suggests a role of ceramides in obesity-associated low-grade inflammation.