Estrogen receptor α-NOTCH1 axis enhances basal stem-like cells and epithelial-mesenchymal transition phenotypes in prostate cancer.

Yongmei ShenJiasong CaoZhixian LiangQimei LinJianxi WangXu YangRan ZhangJiaojiao ZongXiaoling DuYanfei PengJu ZhangJiandang Shi

Published in: Cell communication and signaling : CCS (2019)

Our results implicated CD49f+/ERα + prostate cancer cells associated with basal stem-like and EMT features, named EMT-PCBSLCs, in heightened potential for promoting metastasis. NOTCH1 was regulated by E2 in CD49fHi EMT-PCBSLCs. These results contribute to insights into the metastatic mechanisms of EMT-PCBSLCs in PCa.

Keyphrases

epithelial mesenchymal transition
estrogen receptor
prostate cancer
transforming growth factor
signaling pathway
cell proliferation
small cell lung cancer
radical prostatectomy
nk cells