Platelet protease activated receptor 4 (PAR 4) receptor genotype is associated with an increased risk of preterm birth.

Rupsa C Boelig Tara J Cahanap Lin Ma Tingting Zhan Vincenzo Berghella Joanna S Y Chan Walter K Kraft Steven E McKenzie

Published in: Journal of thrombosis and haemostasis : JTH (2022)

Platelet receptor PAR4 Thr120 is a common variant associated with an increased risk of placental vascular pathology and preterm birth in homozygous individuals. Although a cohort study cannot establish causation, this strong association warrants further exploration.

Keyphrases

preterm birth
low birth weight
gestational age
binding protein
preterm infants