Bone Marrow Mesenchymal Stromal Cells Can Render Multiple Myeloma Cells Resistant to Cytotoxic Machinery of CAR T Cells through Inhibition of Apoptosis.
Lisa C HolthofJort J van der SchansAfroditi KatsarouRenée PoelsAnne T GelderloosEsther DrentSusan E van Hal-van VeenFengzhi LiSonja ZweegmanNiels W C J van de DonkMaria ThemeliRichard W J GroenTuna MutisPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
These results extend our findings on the negative impact of the microenvironment against immunotherapies and suggest that outcome of CAR T cell or conventional CTL therapies could benefit from inhibition of antiapoptotic proteins upregulated in MM cells through BMMSC interactions.