Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin.
Yanwei ShenShuting LiXin WangMengying WangQi TianJiao YangJichang WangBiyuan WangPeijun LiuJin YangPublished in: Journal of experimental & clinical cancer research : CR (2019)
Our findings provide direct evidence that Thal remodels the abnormal tumor vessel system into a normalized vasculature. Our results may lay solid foundation for the development of Thal as a novel candidate agent to maximize the therapeutic efficacy of chemotherapeutic drugs for solid tumors.
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