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circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.

Shuying ShenYute YangPanyang ShenJun MaBin FangQingxin WangKefan WangPeihua ShiShunwu FanXiang-Qian Fang
Published in: Annals of the rheumatic diseases (2021)
This work highlights the function of the circPDE4B-RIC8A axis in OA joints, as well as its regulation of MAPK-p38, suggesting this axis as a potential therapeutic target for OA.
Keyphrases
  • knee osteoarthritis
  • signaling pathway
  • human health
  • risk assessment