Spatial concordance of DNA methylation classification in diffuse glioma.

Niels VerburgFloris P BarthelKevin J AndersonKevin C JohnsonThomas KoopmanMaqsood M YaqubOtto S HoekstraAdriaan A LammertsmaFrederik BarkhofPetra J W PouwelsJaap C ReijneveldAnnemieke J M RozemullerJeroen A M BeliënRonald BoellaardMichael D TaylorSunit DasJoseph F CostelloWilliam Peter VandertopPieter WesselingPhilip C de Witt HamerRoel G W Verhaak

Published in: Neuro-oncology (2022)

Our results underscore the infiltrative nature of diffuse gliomas and suggest that DNA methylation subtypes are relatively concordant in this tumor type, although some heterogeneity exists.

Keyphrases

dna methylation
low grade
genome wide
high grade
gene expression
machine learning
deep learning
single cell
copy number