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Modelling the structure of a ceRNA-theoretical, bipartite microRNA-mRNA interaction network regulating intestinal epithelial cellular pathways using R programming.

Jeffrey M RobinsonW A Henderson
Published in: BMC research notes (2018)
We developed a network model to identify hypothetical co-regulatory motifs in a miRNA-mRNA interaction network related to epithelial function. A mRNA-miRNA interaction list was generated using KEGG and miRWalk2.0 databases. R-code was developed to quantify and visualize inherent network structures. We identified a sub-network with a high number of shared, targeting miRNAs, of genes associated with cellular proliferation and cancer, including c-MYC and Cyclin D.
Keyphrases
  • signaling pathway
  • transcription factor
  • machine learning
  • cell cycle
  • mass spectrometry
  • cell death
  • drug delivery
  • network analysis
  • big data