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Effective treatment of refractory monoclonal gammopathy-associated pure red cell aplasia with isatuximab, pomalidomide and dexamethasone.

Christian Sebastian MichelEva Marie FehrHildegard NolteJoachim BeckAndreas KreftKatharina Theresa Rauschkolb-OlkBjoern JacobiMatthias TheobaldMarkus Munder
Published in: EJHaem (2024)
Monoclonal gammopathy-associated pure red cell aplasia (MG-PRCA) is characterized by the absence or pronounced hypoplasia of erythroid precursors in the bone marrow, causing reticulocytopenia and a normocytic, normochromic anaemia in a patient with a monoclonal plasma cell dyscrasia. We report here on the successful treatment of MG-PRCA with isatuximab, pomalidomide, and dexamethasone after multiple lines of immunosuppressive and anti-plasma cell-directed treatments.
Keyphrases
  • single cell
  • bone marrow
  • multiple myeloma
  • cell therapy
  • low dose
  • stem cells
  • case report
  • smoking cessation