The 22Rv1 prostate cancer cell line carries mixed genetic ancestry: Implications for prostate cancer health disparities research using pre-clinical models.
Leanne Woods-BurnhamAnamika BasuChristina K Cajigas-Du RossArthur LoveClayton YatesMarino De LeonSourav RoyCarlos A CasianoPublished in: The Prostate (2017)
Considering the mortality disparities associated with PCa, which disproportionately affect African American men, there remains a burden on the scientific community to diversify the availability of biospecimens, including cell lines, for mechanistic studies on potential biological mediators of these disparities. This study is beneficial by identifying another PCa cell line that carries substantial AFR ancestry. This finding may also open the door to new perspectives on previously published studies using this cell line.
Keyphrases
- prostate cancer
- african american
- radical prostatectomy
- healthcare
- mental health
- affordable care act
- case control
- public health
- mycobacterium tuberculosis
- risk factors
- genome wide association study
- cardiovascular events
- type diabetes
- gene expression
- copy number
- health information
- middle aged
- social media
- coronary artery disease