CCR5 Activation Promotes NLRP1-Dependent Neuronal Pyroptosis via CCR5/PKA/CREB Pathway After Intracerebral Hemorrhage.

Jun Yan Weilin Xu Cameron LenahanLei HuangJing WenGaigai LiXin HuWen ZhengArne P Neyrinck Ji-Ping Tang

Published in: Stroke (2021)

CCR5 activation promoted neuronal pyroptosis and neurological deficits after ICH in mice, partially through the CCR5/PKA/CREB/NLRP1 signaling pathway. CCR5 inhibition with MVC may provide a promising therapeutic approach in managing patients with ICH.

Keyphrases

dendritic cells
regulatory t cells
nlrp inflammasome
signaling pathway
brain injury
immune response
pi k akt
oxidative stress