Efficacy and Safety of Long-Term Treatment with Stiripentol in Children and Adults with Drug-Resistant Epilepsies: A Retrospective Cohort Study of 196 Patients.

Simona Balestrini Viola Doccini Alessandra Boncristiano Matteo Lenge Salvatore De Masi Renzo Guerrini

Published in: Drugs - real world outcomes (2022)

Based on our findings, we suggest that stiripentol is an effective and well-tolerated therapeutic option not only in Dravet syndrome but also in other epilepsy syndromes with or without an established genetic aetiology. Response duration was influenced by age at stiripentol initiation across different aetiologies.

Keyphrases

drug resistant
multidrug resistant
acinetobacter baumannii
young adults
genome wide
copy number
dna methylation
cystic fibrosis
replacement therapy