Germline mutations in 12 genes and risk of ovarian cancer in three population-based cohorts.

Joanne Kotsopoulos Cassandra A Hathaway Steven A Narod Lauren R Teras Alpa V Patel Chunling Hu Siddhartha Yadav Fergus J Couch Shelley T Tworoger

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2023)

Our data support guidelines for germline genetic testing for BRCA1 and BRCA2 among women diagnosed with epithelial ovarian cancer; testing for PALB2 may be warranted.

Keyphrases

breast cancer risk
dna repair
polycystic ovary syndrome
electronic health record
genome wide
big data
clinical practice
pregnancy outcomes
dna damage
genome wide identification
bioinformatics analysis
gene expression
cervical cancer screening
insulin resistance
adipose tissue
transcription factor