Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats.
Hsiao-Chi ChuangYi-Ying ChenTa-Chih HsiaoHsiu-Chu ChouHan-Pin KuoPo-Hao FengShu-Chuan HoJen-Kun ChenKai-Jen ChuangKang-Yun LeePublished in: ERJ open research (2020)
In conclusion, short-term exposure to PM1 increased the ACE2 overexpression in lungs. Long-term exposure to PM1 decreased the ACE2 overexpression in emphysema. Air pollution may be a risk for SARS-CoV-2 adhesion during the development of COPD.
Keyphrases
- air pollution
- angiotensin converting enzyme
- lung function
- particulate matter
- angiotensin ii
- chronic obstructive pulmonary disease
- sars cov
- cell proliferation
- heavy metals
- polycyclic aromatic hydrocarbons
- transcription factor
- idiopathic pulmonary fibrosis
- water soluble
- pulmonary fibrosis
- respiratory syndrome coronavirus
- pseudomonas aeruginosa
- staphylococcus aureus