Switching photorelease to singlet oxygen generation by oxygen functionalization of phenothiazine photocages.
Mamata OjhaMoumita BanerjeeSouvik RayAmit Kumar SinghAnakuthil AnoopN D Pradeep SinghPublished in: Chemical communications (Cambridge, England) (2022)
A phenothiazine-based photoremovable protecting group (PRPG) for single and dual release of carboxylic acids was developed. The change in the oxidation state of the sulfur atom of the phenothiazine PRPG resulted in singlet oxygen generation, rather than photorelease. The difference in the photochemistry between oxygen-free and oxygen-functionalized phenothiazine was investigated and supported by DFT calculations.