Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice.
Emily FreemanStéphanie LangloisMarcos F LeybaTarek AmmarZacharie LégerHugh J McMillanJean-Marc RenaudBernard J JasminKyle N Cowan
Published in: Skeletal muscle (2024)
Collectively, our findings suggest that PANX1/Panx1 dysregulation in DMD exacerbates several aspects of the disease. Moreover, our results suggest a potential therapeutic benefit to increasing PANX1 levels in dystrophic muscles.