The Role of the Gut, Urine, and Vaginal Microbiomes in the Pathogenesis of Urinary Tract Infection in Women and Consideration of Microbiome Therapeutics.
Amal NajiDrew SiskinMichael H WoodworthJohn R LeeColleen S KraftNirja MehtaPublished in: Open forum infectious diseases (2024)
The gut, urine, and vaginal microbiomes play significant roles in the pathogenesis of recurrent urinary tract infections (rUTIs). Analysis of these microbiota has shown distinct associations with urinary tract infections. Encouraging data indicate that rUTIs may be responsive to microbiome treatments such as fecal microbiota transplantation, expanding potential treatments beyond antibiotics, hydration, and behavioral interventions. If successful, these nonantibiotic therapies have the potential to increase time between rUTI episodes and reduce the prevalence of multidrug-resistant organisms. In this review, we discuss the role of the 3 microbiomes in the pathogenesis of rUTI and utilization of live biotherapeutic products as therapy for rUTI.
Keyphrases
- urinary tract infection
- multidrug resistant
- gram negative
- polycystic ovary syndrome
- risk factors
- human health
- electronic health record
- drug resistant
- acinetobacter baumannii
- type diabetes
- pregnant women
- machine learning
- pregnancy outcomes
- climate change
- skeletal muscle
- pseudomonas aeruginosa
- drug delivery
- insulin resistance