Ibuprofen protects ventilator-induced lung injury by downregulating Rho-kinase activity in rats.

Liang-Ti HuangChien-Huang LinHsiu-Chu ChouChung-Ming Chen

Published in: BioMed research international (2014)

Ibuprofen attenuated high tidal volume induced pulmonary endothelial hyperpermeability. This protective effect was associated with a reduced Rho-kinase activity.

Keyphrases

protein kinase
high glucose
diabetic rats
endothelial cells
pulmonary hypertension
drug induced
smooth muscle
intensive care unit
mechanical ventilation