Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice.

Rachel BrittonAngela T LiuSanket V RegeJulia M AdamsLily AkrapongpisakDavid LeRaniel Alcantara-LeeRaul A EstradaRebecca RaySara AhadiIan GallagerCindy F YangS Sakura MinamiSteven P BraithwaiteEva CzirrMeghan Kerrisk Campbell

Published in: Brain and behavior (2022)

Here we propose that these changes may be used as molecular and histological readouts that correspond to aging-related behavioral decline. These comprehensive findings, in the context of the published literature, are an important resource toward deepening our understanding of normal aging and provide an important tool for studying aging in mice.

Keyphrases

cognitive decline
mild cognitive impairment
high fat diet induced
systematic review
single molecule
meta analyses