Decay of human immunodeficiency virus (HIV) RNA in seminal plasma and rectal fluid in treatment-naïve adults starting antiretroviral therapy with dolutegravir plus lamivudine or bictegravir/emtricitabine/tenofovir alafenamide.

Comparable HIV-1 RNA decay in BP, SP, and RF was observed between DTG + 3TC and BIC/F/TAF. As shown with triple-drug integrase inhibitor-based regimens, rapid HIV-1 RNA suppression in SP and RF is achieved with DTG + 3TC, despite decay patterns differing from those of BP.