Toxicity and efficacy of Gamma Knife radiosurgery for brain metastases in melanoma patients treated with immunotherapy or targeted therapy-A retrospective cohort study.
Brigitte GatterbauerDorian HirschmannNadine EberherrHelena UntersteinerAnna ChoAbdallah ShaltoutPhilipp GöblFabian FitschekChristian DorferStefan WolfsbergerGregor KasprianChristoph HöllerJosa Maria FrischerPublished in: Cancer medicine (2020)
In MBM patients, complications after GKRS are not significantly increased if IT/TT treatment is performed at the time of or after radiosurgery. Further, a clear benefit in distant control and survival is seen in MBM patients treated with GKRS and checkpoint inhibitors. Thus, concomitant treatment of MBM with GKRS and IT/TT seems to be a safe and powerful treatment option although further prospective studies should be conducted.