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A cautionary note on the selectivity of oncolytic poxviruses.

Bingtao TangZong Sheng GuoDavid L BartlettJia LiuGrant McFaddenJoanna L ShislerEdward J Roy
Published in: Oncolytic virotherapy (2019)
Vaccinia virus vvDD-IL15-Rα is very promising for treating cancer types outside of the brain. However, for cancers located within the brain, myxoma virus vMyx-IL15Rα-tdTr offers a safer alternative.
Keyphrases
  • white matter
  • resting state
  • papillary thyroid
  • cerebral ischemia
  • squamous cell
  • multiple sclerosis
  • childhood cancer
  • disease virus
  • structural basis