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Skeletal parathyroid hormone hyporesponsiveness: a neglected, but clinically relevant reality in chronic kidney disease.

Pieter EvenepoelHanne Skou Jørgensen
Published in: Current opinion in nephrology and hypertension (2024)
Skeletal PTH hyporesponsiveness in CKD has a multifactorial origin, shows important interindividual variability, and is challenging to estimate in clinical practice. The variability in skeletal responsiveness compromises PTH as a biomarker of bone turnover, especially when considering populations that are heterogeneous in ethnicity, demography, kidney function, primary kidney disease and mineral metabolism control, and in patients treated with bone targeting drugs.
Keyphrases
  • bone mineral density
  • clinical practice
  • postmenopausal women
  • soft tissue
  • bone loss
  • chronic kidney disease
  • bone regeneration
  • cancer therapy