BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27.

Jin HeMingjun WuLei XiongYijia GongRenjie YuWeiyan PengLili LiLi LiShaorong TianYan WangQian TaoTing-Xiu Xiang

Published in: Clinical epigenetics (2020)

Low expression of ZBTB16 is associated with its promoter hypermethylation and restoration of ZBTB16 inhibits tumorigenesis. ZBTB16 functions as a tumor suppressor through upregulating ZBTB28 and antagonizing BCL6. Our findings also support the possibility of ZBTB16 being a prognostic biomarker for breast cancer.

Keyphrases

gene expression
transcription factor
small molecule
amino acid